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Specifications
- Antibody Type:Primary
- Antigen Name:TN Antigen
- Antigen Symbol:TN Antigen
- Clonality:Monoclonal
- Conjugation:Unconjugated
- Host:Mouse
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgM
- Reactivity:Human
- Environmentally Preferable:
- Storage Buffer:PBS, pH7.2 with 0.02% sodium azide as preservative.
- Storage Temperature:Keep as concentrated solution, aliquot and store at 4°C. Do not freeze.
- Immunogen:Asialo ovine submaxillary mucin (AOSM).
- Tested Applications:ICC/IF, IHC-P, IHC-Fr
- Purification:Unpurified
- Cat. No.:89353-884
- Supplier no.:GTX82968
Specifications
About this item
Aberrant glycosylation is a hallmark of cancer cells. The blood group precursors T (Thomsen-Friedenreich) and Tn epitopes are shielded in healthy and benign-diseased tissues but uncovered in approx. 90% of carcinomas. T and Tn glycoproteins are specific, autoimmunogenic pancarcinoma antigens. These antigens may also be found in neoplastic blood cells Fundamental chemical and physical aspects of these glycoproteins of primary carcinomas are discussed first. Tn and T epitopes are cell and tissue adhesion molecules, essential in invasion by and metastasis of carcinoma which includes adherent and proliferative phases. Immunohistochemical studies of the extent of Tn antigen expression in primary breast carcinoma demonstrate it highly significant correlation with clinicopathological tumor stages, and hence its value as a reliable prognosticator
Type: Primary
Antigen: TN Antigen
Clonality: Monoclonal
Clone:
Conjugation:
Epitope:
Host: Mouse
Isotype: IgM
Reactivity: Human