This Dounce tissue homogenizer is supplied with two pestles, one "loose" and one "tight", to ensure dissociation of cells into fine particles with minimal damage to cell nuclei

Cited in Biochemistry Laboratory, 2nd Edition, by Rodney Boyer, "Tools for the Preparation of Crude Cell Extracts".

Use the large-clearance pestle for initial reduction of soft tissue. Complete the homogenization with the small-clearance pestle. Particularly useful in enzyme studies where heat build-up must be avoided. Fabricated from borosilicate glass.