Anti-BCL10 Mouse Monoclonal Antibody [clone: 151]

About this item

Monoclonal Anti-BCL-10 reacts specifically with human bcl-10. The epitope recognized by the antibody resides within amino acids 122-168 of human bcl-10 molecule. BCL-10, also designated as CIPER, mE10, cE10, CARMEN, and CLAP, is an N-terminal CARD (caspase recruitment domain) containing protein. It is a cellular homologue of the equine herpesvirus-2 protein E-10 (VCLAP). BCL-10 was implicated in the regulation of apoptosis by interacting with caspase 9, enhancing procaspase 9 processing, and triggering its activation when overexpressed in the cell. Bcl-10 cellular overexpression induces JNK, P38, and NF-kB activation. Deregulation of BCL-10 expression was also demonstrated to be involved in cellular oncogenesis.

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