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Specifications
- Antibody Type:Primary
- Antigen Name:Procathepsin K
- Antigen Symbol:PK
- Clonality:Polyclonal
- Clone:Polyclonal
- Conjugation:Unconjugated
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human
- Western Blot:Yes
- Size:0.1 mg
- Environmentally Preferable:
- Form:The antibody is lyophilized in 0.05 M phosphate buffer, 0.1 M NaCl, pH 7.2. AZIDE FREE.
- Antigen Synonyms:procathepsin K
- Storage Buffer:Add 0.2 ml of deionized water and let the lyophilized pellet dissolve completely. Slight turbidity may occur after reconstitution, which does not affect activity of the antibody. In this case clarify the solution by centrifugation.
- Shipping Temperature:At ambient temperature
- Purification:Immunoaffinity chromatography on a column with immobilized recombinant Human Procathepsin K.
- Cat. No.:101189-786
- Supplier no.:RD181074100
Specifications
About this item
Quality control test, Indirect ELISA – to determine titer of the antibody , SDS PAGE – to determine purity of the antibody, and BCA - to determine quantity of the antibody.
Human cathepsin K (EC 3.4.22.38) is a member of the cysteine protease (papain) family with high primary sequence homology to cathepsins S, L, and B. It has been shown that cathepsin K plays a major role in the resorption of the bone matrix by osteoclasts. Cathepsin K has a potential as a drug target for the diseases related to bone matrix metabolism such as osteoporosis. Autoproteolytic processing of the N-terminal 99 amino acid propeptide produces the active, mature form of cathepsin K. It is presumed that the activation of procathepsin K in vivo occurs in the bone resorption pit, which has a low-pH environment. Humans lacking cathepsin K exhibit pycnodysostosis, which is characterized by short stature and osteosclerosis.
Storage temperature: The lyophilized antibody remains stable and fully active until the expiry date when stored at –20 °C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles and store frozen at –80 °C. Reconstituted antibody can be stored at 4 °C for a limited period of time; it does not show decline in activity after one week at 4 °C.