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Specifications
- Antibody Type:Primary
- Antigen Name:Pancreatic secretory granule membrane major glycoprotein GP2
- Antigen Symbol:GP2
- Clonality:Monoclonal
- Clone:GP2/1712
- Conjugation:Unconjugated
- Flow Cytometry:Yes
- Host:Mouse
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG2b lambda
- Reactivity:Human
- Size:100 ug
- Environmentally Preferable:
- Format:Purified Antibody
- Form:Liquid
- Gene ID:P55259
- Antigen Synonyms:GP2
- Storage Buffer:PBS with 0.1 mg/ml BSA and 0.05% sodium azide
- Storage Temperature:Aliquot and Store at 2…8 °C. Avoid freez-thaw cycles.
- Concentration:0.2 mg/mL
- Shipping Temperature:4 °C
- Immunogen:A partial human recombinant protein corresponding to amino acids 35-179 was used as the immunogen for the GP2 antibody.
- Purification:Protein G affinity chromatography
- Cat. No.:76194-606
Specifications
About this item
GP2 (Glycoprotein 2), also known as ZAP75, is a 537 amino acid secreted protein. It is an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. GP2 is cleaved and then released into the pancreatic duct along with exocrine secretions. GP2 binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). GP2 is also expressed on the apical plasma membrane of specialized microfold (M) cells among enterocytes and serves as a transcytotic receptor for mucosal antigens. M cells are considered a promising target for oral vaccination against various infectious diseases.
Flow Cytometry: 0.5-1ug/10e6 cells in 0.1ml Immunofluorescence: 0.5-1 ug/ml IHC (FFPE): 1-2 ug/ml for 30 min at RT Optimal dilution of the GP2 antibody should be determined by the researcher.
Type: Primary
Antigen: GP2
Clonality: Monoclonal
Clone: GP2/1712
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2b, lambda
Reactivity: Human