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Specifications
- Antibody Type:Primary
- Antigen Name:Baculoviral IAP Repeat Containing 6
- Antigen Symbol:BIRC6
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:
- Reactivity:Human
- Size:100 µg
- Environmentally Preferable:
- Epitope:C-Terminal
- Format:IgG
- Form:Liquid (sterile filtered)
- Gene ID:57448
- Antigen Synonyms:BRUCE|Baculoviral IAP repeat-containing protein 6|APOLLON|KIAA1289|BIR repeat-containing ubiquitin-conjugating enzyme
- Concentration:1 mg/mL by UV absorbance at 280 nm
- Shipping Temperature:Dry Ice
- Immunogen:Anti-BRUCE antibody was prepared from whole rabbit serum produced by repeated immunizations with a 17 amino acid synthetic peptide near the C-terminus of human BRUCE.
- Purification:Anti-BRUCE Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. BRUCE antibody is human specific. Multiple isoforms of BRUCE are known to exist.
- Cat. No.:10800-478
- Supplier no.:600-401-Z94
Specifications
About this item
Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. BRUCE, also known as BIRC6, is an IAP family member protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. BRUCE regulates p53 and the mitochondrial pathway of apoptosis by facilitating the degradation of apoptotic proteins such as Caspase-9 and SMAC by ubiquitination.
Recommended Dilutions: ELISA: User Optimized; Immunohistochemsitry: 5 µg/mL ; contains 0.02% (w/v) Sodium Azide
Type: Primary
Antigen: BIRC6
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: C-Terminal
Host: Rabbit
Isotype:
Reactivity: Human