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Specifications
- Antibody Type:Primary
- Antigen Name:Autophagy Related 4C
- Antigen Symbol:ATG4C
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:
- Reactivity:Human,Rat,Mouse
- Western Blot:Yes
- Size:100 µg
- Environmentally Preferable:
- Epitope:C-Terminal
- Format:IgG
- Form:Liquid (sterile filtered)
- Gene ID:84938
- Antigen Synonyms:APG4-C|Autophagy-related protein 4 homolog C,|AUTL3|ATG4 autophagy related 4 homolog C (S. cerevisiae)|autophagin-3|AUTL1|APG4C|ATG4C|FLJ14867
- Concentration:1 mg/mL by UV absorbance at 280 nm
- Shipping Temperature:Dry Ice
- Immunogen:Anti-ATG4C antibody was prepared from whole rabbit serum produced by repeated immunizations with an 18 amino acid peptide near the C-terminus of human ATG4C
- Purification:Anti-ATG4C antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. ATG4C antibody is human, mouse and rat reactive. ATG4C is predicted to not cross-react with other ATG4 proteins.
- Cat. No.:10800-212
- Supplier no.:600-401-Y84
Specifications
About this item
Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1,2). ATG4C, also known as autophagin-3, is one of four mammalian orthologs of the yeast ATG4 protein; all four are cysteine proteases (3). Recent studies have shown that ATG4C and Beclin-1 are regulated by the microRNA miR-376b; overexpression of miR-376b led to decreased mRNA and protein levels, thereby blocking starvation and TOR inhibition-related autophagy (4).
Recommended Dilutions: ELISA: 1:10,000-1:20,000; Immunohistochemsitry: 5 ?g/mL; Immunofluorescence Microscopy: 20 ?g/mL; Western Blot: 1 - 2 µg/mL; contains 0.02% (w/v) Sodium Azide
Type: Primary
Antigen: ATG4C
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: C-Terminal
Host: Rabbit
Isotype:
Reactivity: Human, Mouse, Rat