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Specifications
- Antibody Type:Primary
- Antigen Name:mitogen-activated protein kinase kinase kinase 5
- Antigen Symbol:MAP3K5
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human,Mouse
- Western Blot:Yes
- Size:0.02 mg
- Environmentally Preferable:
- Epitope:near the N-Terminus
- Cross Adsorption:No
- Form:Liquid
- Gene ID:Q99683
- Antigen Synonyms:MAP3K5
- Storage Buffer:ASK1 Antibody is supplied in PBS containing 0.02% sodium azide.
- Storage Temperature:ASK1 antibody can be stored at 4 °C for three months and –20 °C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Concentration:1 mg/mL
- Shipping Temperature:4 °C
- Immunogen:ASK1 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human ASK1. The immunogen is located within amino acids 390 - 440 of ASK1.
- Purification:ASK1 Antibody is affinity chromatography purified via peptide column.
- Cat. No.:10748-522
- Supplier no.:3679_S
Specifications
About this item
ASK1 Antibody: Mitogen-activated protein (MAP) kinase cascades are activated in response to various extracellular stimuli, including cytokines, growth factors and environmental stresses. A novel MAP kinase kinase kinase (MAPKKK) was recently identified and designated ASK1 (for apoptosis signal-regulating kinase 1) and MAPKKK5. ASK1 activated two different subgroups of MAPKK, MKK4 and MKK6, which in turn activated c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induced apoptotic cell death, and a catalytically inactive form of ASK1 inhibited TNF-alpha -induced apoptosis. ASK1 is expressed in variety of tissues and cell lines.
Type: Primary
Antigen: MAP3K5
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse