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Specifications
- Antibody Type:Primary
- Antigen Name:Fibroblast Growth Factor 2
- Antigen Symbol:FGF2
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Host:Sheep
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Western Blot:Yes
- Size:100 µL
- Environmentally Preferable:
- Cross Adsorption:No
- Format:Lyophilized
- Antigen Synonyms:BFGF|HBGF-2|FGF-2|Basic fibroblast growth factor|Fibroblast growth factor|Fibroblast growth factor 2|FGFB
- Immunogen:Recombinant human basic FGF
- Cat. No.:10782-612
- Supplier no.:S-008-100
Specifications
About this item
Fibroblast growth factors (FGFs), a heparin binding growth factor, exhibit widespread mitogenic and neurotrophic activities in a variety of different cells including mesenchymal, neuroectodermal and endothelial cells. aFGF (FGF-1) and bFGF (FGF-2) are present in relatively high levels in CNS. aFGF is expressed by a subset of neuronal populations, while bFGF is expressed by astrocytes, both lack signal peptides. Human bFGF is a 17.2 kDa protein containing 155 amino acid residues. FUNCTION: The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors. SUBUNIT: Monomer. Interacts with CSPG4 and FGFBP1. Found in a complex with FGFBP1, FGF1 and FGF2. MISCELLANEOUS: This protein binds heparin more strongly than does aFGF. SIMILARITY: Belongs to the heparin-binding growth factors family.
A high level of specificity for bFGF was shown by immunohistochemistry for this antiserum.
Application Information:
IHC (frozen), WB. Recommended to be used at a dilution of 1: 1000 to 1:2000 for both applications. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Type: Primary
Antigen: rh Basic FGF
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: Multiple points of reactivity likely because of the polyclonal nature of the antibody
Host: Sheep
Isotype: IgG
Reactivity: Human, Mouse, Rat