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Specifications
- Antibody Type:Primary
- Antigen Name:Sprouty-Related, EVH1 Domain Containing 2
- Antigen Symbol:SPRED2
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Western Blot:Yes
- Size:150 µL
- Environmentally Preferable:
- Antigen Synonyms:EVH1 domain-containing protein 2|Spred-2|Sprouty-related
- Storage Buffer:PBS with 0.0.2% sodium azide and 50% glycerol pH 7.3.
- Shipping Temperature:Store at -20°C
- Immunogen:Fusion Protein
- Purification:Antigen Affinity Purified
- Cat. No.:10095-122
- Supplier no.:24091-1-AP
Specifications
About this item
SPRED2 is a member of the SPRED family of proteins that modulate growth factor receptor signaling by inhibiting the Ras-MAPK cascade . SPRED family members are characterized by an N-terminal Enabled/VASP homology 1 domain (EVH1), a central c-Kit binding domain (KBD) and a C-terminal Sprouty-related domain (SPR) . Three mammalian SPREDs (SPRED1-3) have been described. In adult tissues, SPRED2 is expressed ubiquitously, but most highly expressed in glandular epithelia . Reduced expression level of SPRED2 has been reported in human hepatocellular carcinoma (HCC), suggesting SPRED2 may play a role in tumorgenesis . Gene disruption of SPRED2 causes dwarfism .
Western Blot: Mouse Testis Tissue, 1:500-1:5000; IHC: Human Testis Tissue, 1:20-1:200
Type: Primary
Antigen: SPRED2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat