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Specifications
- Antibody Type:Primary
- Antigen Name:Regulation Of Nuclear Pre-MRNA Domain Containing 1A
- Antigen Symbol:RPRD1A
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Rabbit
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Human,Mouse
- Western Blot:Yes
- Size:150 µL
- Environmentally Preferable:
- Antigen Synonyms:P15RS|P15INK4B-Related Protein
- Storage Buffer:PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
- Shipping Temperature:Store at -20°C
- Immunogen:Fusion Protein
- Purification:Antigen affinity Purification
- Cat. No.:10090-930
- Supplier no.:23652-1-AP
Specifications
About this item
RPRD1A is upregulated in cells overexpressing cyclin-dependent kinase inhibitor p15(INK4b) and may have a role in cell cycle regulation. It contains a RAR domain that is involved in regulation of nuclear pre-mRNA, which suggests that P15RS may act as a nuclear regulation protein . It also interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. Besides, RPRD1A regulates cell cycle genes and attenuates WNT signaling , and acts as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle .
Western Blot: Mouse Skeletal Muscle Tissue, 1:500-1:5000; IF: HepG2 Cells, 1:20-1:200
Type: Primary
Antigen: RPRD1A
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse