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Specifications
- Antibody Type:Primary
- Antigen Name:DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
- Antigen Symbol:DDX58
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Rabbit
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Human,Mouse
- Western Blot:Yes
- Size:150 µL
- Environmentally Preferable:
- Antigen Synonyms:Probable ATP-dependent RNA helicase DDX58|DEAD box protein 58|RIGI|RIG-I|RIG-1|RLR-1
- Storage Buffer:PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
- Shipping Temperature:Store at -20°C
- Immunogen:Peptide
- Purification:Antigen affinity Purification
- Cat. No.:10081-718
- Supplier no.:20566-1-AP
Specifications
About this item
DDX58, also named as RIG-1, belongs to the helicase family. It is involved in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). It is essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza viruses, Japanese encephalitis virus and HCV. The antibody is specific to DDX58.
Western Blot: HepG2 Cells, 1:500-1:5000; IF: HepG2 Cells, 1:10-1:100
Type: Primary
Antigen: DDX58
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse