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Specifications
- Antibody Type:Primary
- Antigen Name:ISG15 Ubiquitin-like Modifier
- Antigen Symbol:ISG15
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human
- Western Blot:Yes
- Size:150 µL
- Environmentally Preferable:
- Antigen Synonyms:interferon-induced 17 kDa protein|ubiquitin cross-reactive protein|interferon|alpha-inducible protein (clone IFI-15K)|IP17|hUCRP|interferon-stimulated protein|UCRP|IFI15|G1P2|interferon-induced 15 kDa protein|interferon-induced 17-kDa/15-kDa protein|15 kDa|ubiquitin-like protein ISG15
- Storage Buffer:PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
- Shipping Temperature:Store at -20°C
- Immunogen:Recombinant Protein
- Purification:Antigen affinity Purification
- Cat. No.:10088-988
- Supplier no.:15981-1-AP
Specifications
About this item
ISG15 is a ubiquitin-like protein that becomes conjugated to many cellular proteins upon activation by interferon-alpha (IFNA) and -beta (IFNB). ISG15 forms covalent conjugates with its target proteins in a process called ISGylation, which in mammals is known to play a role in antiviral immunity. ISG15 proteins possess two ubiquitin-like (UBL) domains and a highly conserved C-terminal LRGG sequence, the latter being known as the ubiquitin conjugation motif. Intracellular ISG15 are conjugated, via the LRGG motif, to target proteins through a process called ISGylation, which resembles largely ubiquitination, the process of formation of ubiquitin conjugates. Unconjugated extracellular ISG15, which are released from several types of human and murine cells, are known to possess cytokine-like activity.
Western Blot: Human Brain Tissue, 1:200-1:2000; IHC: Human lung cancer Tissue, 1:20-1:200
Type: Primary
Antigen: ISG15
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human