Factor Xa Protease, New England Biolabs

Factor Xa cleaves after the arginine residue in its preferred cleavage site Ile-(Glu or Asp)-Gly-Arg

It will sometimes cleave at other basic residues, depending on the conformation of the protein substrate. The most common secondary site, among those that have been sequenced, is Gly-Arg. There seems to be a correlation between proteins that are unstable in E. coli and those that are cleaved by Factor Xa at secondary sites; this may indicate that these proteins are in a partially unfolded state. Factor Xa will not cleave a site followed by proline or arginine.

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