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Specifications
- Antibody Type:Primary
- Antigen Symbol:Cardif
- Clonality:Monoclonal
- Clone:Adri-1
- Conjugation:Unconjugated
- Host:
- ImmunoChemistry:Yes
- ImmunoPrecipitation:Yes
- Isotype:IgG2b
- Reactivity:Human
- Western Blot:Yes
- Size:100 µg
- Environmentally Preferable:
- Form:Liquid
- Gene ID:Q7Z434
- Antigen Synonyms:CARD Adapter Inducing Interferon-beta|Virus-induced Signaling Adapter|MAVS|Interferon-beta Promoter Stimulator Protein 1|VISA|IPS-1|Mitochondrial Antiviral Signaling Protein
- Storage Buffer:In PBS containing 10% glycerol and 0.02% sodium azide.
- Storage Temperature:Short term: +4 °C, Long Term: –20 °C
- Concentration:1mg/ml
- Shipping Temperature:-20° C
- Immunogen:Recombinant human Cardif (aa 160-450).
- Cat. No.:102514-260
- Supplier no.:AG20B0004C100
Specifications
About this item
RIG-I (retinoic acid-inducible gene I; Ddx58) and MDA5 (melanoma differentiation-associated gene 5, also known as Ifih1 or Helicard) are proteins that sense viral replication intermediates, such as double-stranded RNA and triggers the host antiviral programs. These molecules signal the downstream activation of NF-kappaB and IFN regulatory factor (IRF) -3, which coordinately regulate the expression of type-I interferons. Cardif (also called VISA/IPS-1/MAVS) is a new CARD (caspase activation and recruitment domain)-containing adaptor protein that interacts with the CARD domain of RIG-I and MDA5, leading to the activation of NF-kappaB and IRF3. Cardif is located to the mitochondrial outer membrane. Removal of the mitochondrial-targeting domain of cardif abolishes its ability to induce IFNs. Cardif is cleaved and inactivated by NS3-4A, a serine protease from hepatitis C virus known to block interferon-beta production.
- Stable for at least 1 year after receipt when stored at -20°C.
Purified from concentrated hybridoma tissue culture supernatant.
Purity: >95% (SDS-PAGE)
Type:
Antigen: Cardif
Clonality: Monoclonal
Clone: Adri-1
Conjugation:
Epitope:
Host: Mouse
Isotype: IgG2b
Reactivity: Human