Anti-HSP70 Mouse Monoclonal Antibody (Biotin)

The Hsp70 family of heat shock proteins contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

For Western Blot

Recognizes human, mouse, rat, avian, hamster, monkey, rabbit, guinea pig, bovine, chicken, sheep, chicken, fish, pig and beluga HSP70 (HSP72). Detects a band of ~70kDa by Western blot.

Type: Primary
Antigen: HSP70
Clonality: Monoclonal
Clone:
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human

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Catalog No:
200062-684
200062-682

Antigen Symbol:
HSP70
HSP70

Antigen Name:
Heat Shock Protein 70
Heat Shock Protein 70

Antigen Synonyms:
HSP70.1/HSP70.2|HSPA1|HSPA1A|HSP-70|HSPA1B|HSP70-1/HSP70-2|Heat shock 70 kDa protein 1A/1B|Heat shock 70 kDa protein 1/2|HSX70|HSP 70
HSP70.1/HSP70.2|HSPA1|HSPA1A|HSP-70|HSPA1B|HSP70-1/HSP70-2|Heat shock 70 kDa protein 1A/1B|Heat shock 70 kDa protein 1/2|HSX70|HSP 70