Anti-Protocadherin-Gamma-A1 Mouse Monoclonal Antibody (BAC) [Clone: S159-5]

Catalog # 75931-220

Catalog # 75931-220

Supplier Number: 200-306-W68

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Specifications

Antibody Type:
Primary
Antigen Name:
Protocadherin-Gamma-A1
Clonality:
Monoclonal
Clone:
S159-5
Conjugation:
Biotin
ELISA:
Yes
Host:
Mouse
Isotype:
IgG1
Reactivity:
Western Blot:
Yes
Size:
100 µg
Environmentally Preferable:
Storage Temperature:
Store vial at –20 °C. Aliquot contents and freeze at –20 °C. Centrifuge product if not completely clear after standing at room temperature. Stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use.
Shipping Temperature:
Wet Ice
Purification:
Protein G purified
Cat. No.:
75931-220
Supplier no.:
200-306-W68

Specifications

About this item

The protocadherin gamma gene cluster is one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes.
The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. Anti-Protocadherin Gamma (pan) is ideal for research in Neuroscience, Cell Adhesion and Cell Signaling.

Anti-Protocadherin Gamma (pan) Biotin Conjugated Antibody is suitable for Western Blots and Immunocytochemistry. Expect a band approximately ~100 kDa on specific lysates or tissues. It will cross react with all Gamma-protocadherins -A, -B, and -C. Specific conditions for reactivity should be optimized by the end user.

Type: Primary
Antigen: Protocadherin-Gamma-A1
Clonality: Monoclonal
Clone: S159-5
Conjugation: BAC
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: