- Antibody type:Primary
- Antigen name:ATF4/CREB-2
- Clonality:Polyclonal
- Conjugation:Cy7®
- Flow cytometry:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Rabbit,Human,Dog,Rat,Mouse
- Western blot:Yes
- Environmentally Preferable:
- Epitope:251-351/351
- Form:Liquid
- Gene ID:468
- Antigen synonyms:DNA-binding protein TAXREB67|TAXREB67|cAMP-dependent transcription factor ATF-4|Cyclic AMP-dependent transcription factor ATF-4|TXREB|Tax-responsive enhancer element-binding protein 67|CREB2|Activating transcription factor 4|cAMP-responsive element-binding protein 2|CREB-2|Cyclic AMP-responsive element-binding protein 2|ATF4
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:38 kDa
- Storage temperature:Store at –20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human ATF4
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes.
Type: Primary
Antigen: ATF4/CREB-2
Clonality: Polyclonal
Clone:
Conjugation: Cy7
Public Immunogen Range: 251-351/351
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat, Dog, Rabbit