Specifications
- Antibody type:Primary
- Antigen name:FGFR1/FGFR2 Tyr463/Tyr466
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 680
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Human,Rat
- Western blot:Yes
- Environmentally Preferable:
- Form:Liquid
- Gene ID:2260, 2263
- Antigen synonyms:Heparin binding growth factor receptor|BFGFR|N sam tyrosine kinase|Fms related tyrosine kinase 2 Pfefer syndrome|FLG protein|Fibroblast growth factor receptor 1|KAL 2|FGFR 1|CD 331|FLT 2|HBGFR|KAL2|FLT2|Fms like tyrosine kinase 2|H4|N SAM|Fms related tyrosine kinase 2|Basic fibroblast growth factor receptor 1|FLG|Hydroxyaryl protein kinase|CD331 antigen|H5|CEK|C FGR|FLJ14326|H3|CD331|H2|Tyrosylprotein kinase|bFGF R|Protein tyrosine kinase|FGFBR|MFR
- Modification:Phosphorylation (Tyr463/Tyr466)
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:88 kDa
- Storage temperature:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic phosphopeptide derived from human FGFR1 around the phosphorylation site of Tyr463
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Specifications
About this item
Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through the cellular surface tyrosine kinase receptors. There are four members of the FGF receptor family: FGFR-1 (flg), FGFR-2 (bek, KGFR), FGFR-3 and FGFR-4. Each receptor contains an extracellular ligand binding domain, a transmembrane region and a cytoplasmic kinase domain (1). Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues (2). Seven tyrosine residues in the cytoplasmic tail of FGFR-1 can be phosphorylated: Tyr463, Tyr583, Tyr585, Tyr653, Tyr654, Tyr730 and Tyr766. Tyrosine 653 and 654 are important for catalytic activity of the activated FGFR and are essential for signaling (3). The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components such as Crk and PLCgamma.
Type: Primary
Antigen: FGFR1/FGFR2 Tyr463/Tyr466
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range:
Host: Rabbit
Isotype: IgG
Reactivity: Human; Rat