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Anti-CBL2 Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Anti-CBL2 Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Catalog # BOSSBS-5147R-A750
Supplier:  Bioss
Anti-CBL2 Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Catalog # BOSSBS-5147R-A750
Supplier:  Bioss

Specifications

  • Antibody type:
    Primary
  • Antigen name:
    CBL2
  • Clonality:
    Polyclonal
  • Conjugation:
    Alexa Fluor® 750
  • Host:
    Rabbit
  • ImmunoChemistry:
    Yes
  • ImmunoFluorescence:
    Yes
  • Isotype:
    IgG
  • Reactivity:
  • Western blot:
    Yes
  • Environmentally Preferable:
  • Epitope:
    241-340/906
  • Form:
    Liquid
  • Gene ID:
    867
  • Antigen synonyms:
    RING finger protein 55|Cas Br M murine ecotropic retroviral transforming sequence|Oncogene CBL2|Casitas B-lineage lymphoma proto-oncogene|E3 ubiquitin-protein ligase CBL|CBL C|cbl|Proto oncogene c CBL|CBL 2|Signal transduction protein CBL|E3 ubiquitin protein ligase CBL|CBL_HUMAN|CBL2|Proto-oncogene c-CBL|C CBL|RGD1561386|RNF55|Cas-Br-M murine ecotropic retroviral transforming sequence|Casitas B lineage lymphoma proto oncogene
  • Modification:
    Unmodified
  • Storage buffer:
    Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
  • Molecular weight:
    99 kDa
  • Storage temperature:
    Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
  • Concentration:
    1 µg/µl
  • Shipping temperature:
    4 °C
  • Immunogen:
    KLH conjugated synthetic peptide derived from human C CBL
  • Tested applications:
    ICC
  • Purification:
    Purified by Protein A
  • Pack type:
    Vial
  • Pk:
    100 µl

Specifications

About this item

This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder.

Type: Primary
Antigen: CBL2
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 241-340/906
Host: Rabbit
Isotype: IgG
Reactivity: