- Antibody type:Primary
- Antigen name:HDPTP
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 647
- Flow cytometry:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Human,Rat
- Western blot:Yes
- Environmentally Preferable:
- Epitope:1501-1636/1636
- Form:Liquid
- Gene ID:25930
- Antigen synonyms:PTPN 23|PTPN23|protein tyrosine phosphatase TD14|Protein tyrosine phosphatase TD 14|PTP-TD14|protein tyrosine phosphatase non-receptor type 23|PTN23_HUMAN|Tyrosine-protein phosphatase non-receptor type 23|HD PTP|HDPTP|His domain-containing protein tyrosine phosphatase|PTP TD14|HD-PTP|DKFZP564F0923|Protein tyrosine phosphatase non receptor type 23|His domain protein tyrosine phosphatase|Tyrosine protein phosphatase non receptor type 23|His domain containing protein tyrosine phosphatase|EC 3,1,3,48|KIAA1471
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:179 kDa
- Storage temperature:Store at –20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human HDPTP
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
HD-PTP is a 1636 amino acid protein encoded by the human gene PTPN23. HD-PTP belongs to the protein-tyrosine phosphatase family, non-receptor class subfamily. It contains one BRO1 domain, two TPR repeats and one tyrosine-protein phosphatase domain. The C-terminal region contains the PTP-like domain, whereas the N-terminal region contains the two TPR regions. These regions are homologous to the yeast protein, BRO1, which is involved in the mitogen-activated protein kinase signaling pathway. Similarly, HD-PTP is believed to act as a negative regulator of Ras-mediated mitogenic activity and is phosphorylated upon DNA damage, probably by ATM or ATR. HD-PTP protein is differentially modulated by two angiogenic growth factors. While Vascular Endothelial Growth Factor (VEGF) has no affect on protein levels, Fibroblast Growth Factor-2 (FGF-2) induces HD-PTP degradation via the proteasome system.
Type: Primary
Antigen: HDPTP
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 647
Public Immunogen Range: 1501-1636/1636
Host: Rabbit
Isotype: IgG
Reactivity: Human; Rat