Specifications
- Antibody type:Primary
- Antigen name:angiopoietin like 4
- Antigen symbol:ANGPTL4
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Rabbit
- Isotype:
- Reactivity:Human
- Western blot:Yes
- Environmentally Preferable:
- Form:Liquid
- Gene ID:51129
- Antigen synonyms:Hepatic Fibrinogen/Angiopoietin-related Protein|Fasting-induced Adipose Factor|HFARP|FIAF|Angiopoietin-like Protein 4
- Storage buffer:0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.
- Storage temperature:Stable for at least 6 months after receipt when stored at -20˚C.
- Concentration:1 mg/ml
- Shipping temperature:-20°C
- Immunogen:Synthetic peptide corresponding to aa 79-101 (A79CQGTEGSTDLPLAPESRVDPEV101) of human ANGPTL4.
- Size:100 μg
- Pk:100 µG
Specifications
About this item
ANGPTL4 mainly expressed in endothelial cells (hypoxia-induced). Regulates angiogenesis and modulates tumorgenesis and directly regulates lipid, glucose, and energy metabolism. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 is a protein consisting of an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain (FLD). Both domains have distinct biological functions. The coiled-coil domain is responsible for the inhibitory effects on lipoprotein lipase (LPL) converting the active form of LPL into an inactive form, and the FLD domain mediates its antiangiogenic functions. The coiled coil and the FLD domains are separated by a short linker that can be cleaved after secretion. ANGPTL4 appears on the cell surface as the full-length form, where it can be released by heparin treatment. ANGPTL4 protein is then proteolytically cleaved by proprotein convertases (PCs), including furin, PC5/6, paired basic amino acid-cleaving enzyme 4, and PC7.
Type: Primary
Antigen: ANGPTL4
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity: Human