Anti-CASP4 Rat Monoclonal Antibody [clone: 8A5]
PRSI36-182
- Antibody type:Primary
- Antigen name:Caspase 4
- Antigen symbol:CASP4
- Clonality:Monoclonal
- Clone:8A5
- Conjugation:Unconjugated
- ELISA:Yes
- Flow cytometry:Yes
- Host:Rat
- ImmunoPrecipitation:Yes
- Isotype:IgG1 kappa
- Reactivity:Rat,Mouse
- Western blot:Yes
- Environmentally Preferable:
- Form:Liquid
- Gene ID:12363
- Antigen synonyms:ICE(rel)III|ICH-3|caspase 5|caspase-5|CASP-4|Mih1/TX|CASP-5|caspase 4|protease ICH-2|ICEREL-III|ICE(rel)-III|caspase-4|protease TY|protease ICH-3|ICE(rel)II|TY protease|TX|ICE(rel)-II|ICH-2|apoptosis-related cysteine protease|apoptotic cysteine protease Mih1/TX|ICEREL-II|protease TX
- Storage buffer:In PBS containing 0.02% sodium azide.
- Storage temperature:Stable for at least 1 year after receipt when stored at -20˚C.
- Concentration:1 mg/ml
- Shipping temperature:-20°C
- Immunogen:Recombinant mouse caspase-11 (p20 fragment).
- Tested applications:FACS,
- Purification:>95% (SDS-PAGE)
- Size:100 μg
- Pk:100 µG
Caspase-11 not only activates caspase-1, that is required for the maturation of proinflammatory cytokines such as interleukin-1 (IL-1) and interleukin-18 (IL-18), but also activates caspase-3, leading to cellular apoptosis under pathological conditions. In most cells, caspase-11 is only expressed upon induction with pro-inflammatory stimuli. Caspase-11 is an essential mediator of endotoxic shock and caspase-11-deficient mice are resistant to endotoxic shock. LPS-induced caspase-11 regulates lymphocyte apoptosis by activating both caspase-3 and caspase-7.
Type: Primary
Antigen: CASP4
Clonality: Monoclonal
Clone: 8A5
Conjugation: Unconjugated
Epitope:
Host: Rat
Isotype: IgG1 kappa
Reactivity: Mouse, Rat