Anti-NLRP3 Mouse Monoclonal Antibody [clone: Cryo-1]
Catalog # PRSI36-099
Supplier: ProSci Inc.
Specifications
- Antibody type:Primary
- Antigen name:NLR Family, pyrin Domain Containing 3
- Antigen symbol:NLRP3
- Clonality:Monoclonal
- Clone:Cryo-1
- Conjugation:Unconjugated
- Host:Mouse
- Isotype:IgG2b
- Reactivity:Mouse
- Western blot:Yes
- Environmentally Preferable:
- Form:Liquid
- Gene ID:216799
- Antigen synonyms:MWS|AII|LRR and PYD domains-containing protein 3|FCU|AGTAVPRL|cryopyrin|NACHT|and PYD-containing protein 3|NALP3|cold autoinflammatory syndrome 1 protein|C1orf7|CLR1.1|AVP|leucine-rich repeat-|CIAS1|nucleotide-binding oligomerization domain|FCAS|PYRIN-containing APAF1-like protein 1|leucine rich repeat and pyrin domain containing 3|PYPAF1|caterpiller protein 1.1|LRR and PYD containing protein 3|NACHT domain-
- Storage buffer:In PBS containing 10% glycerol and 0.02% sodium azide.
- Storage temperature:Stable for at least 1 year after receipt when stored at -20˚C.
- Concentration:1 mg/ml
- Shipping temperature:-20°C
- Immunogen:Recombinant mouse NLRP3/NALP3 (pyrin domain/aa 1-93).
- Purification:>95% (SDS-PAGE)
- Size:100 μg
- Pk:100 µG
Specifications
About this item
The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor family, including NLRP3/NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckle-Wells syndrome (MWS) and of chronic infantile neurologic cutaneous and articular syndrome (CINCA).
Type: Primary
Antigen: NLRP3
Clonality: Monoclonal
Clone: Cryo-1
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2b
Reactivity: Mouse