- Antigen name:Transmembrane emp24 domain-containing protein 10
- Antigen symbol:TMED10
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Western blot:Yes
- Environmentally Preferable:
- Antigen synonyms:TMED10|Tmp 21 I|21 kDa transmembrane trafficking protein|Transmembrane protein Tmp21|TMED 10|Transmembrane emp24 domain containing protein 10|S31III125|p23|Transmembrane trafficking protein 21kD|S31I125|1110014C03Rik|Transmembrane emp24-like trafficking protein 10 yeast|MGC102351|p24delta|p24delta1|TMEDA_HUMAN.|p24 family protein delta 1|Tmp 21
- Storage buffer:PBS containing 0.02% sodium azide
- Immunogen:TMP21 antibody was raised against a 18 amino acid synthetic peptide from near the center of human TMP21.
- Tested applications:E, WB, IHC
- Purification:Affinity chromatography purified via peptide column
- Size:100 µg
- Pk:100 µG
TMP21 Antibody: TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer's disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased gamma-secretase activity but not epsilon-secretase activity, and increased Abeta; production, demonstrating that TMP21 can modulate gamma-secretase activity.
Type:
Antigen: TMED10
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat