Anti-ILP2 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog # BOSSBS-6870R-A680

Supplier: Bioss

Catalog # BOSSBS-6870R-A680

Supplier: Bioss

Specifications

Antibody type:
Primary
Antigen name:
ILP2
Clonality:
Polyclonal
Conjugation:
Alexa Fluor® 680
Host:
Rabbit
ImmunoChemistry:
Yes
ImmunoFluorescence:
Yes
Isotype:
IgG
Reactivity:
Rat
Environmentally Preferable:
Epitope:
141-236/236
Form:
Liquid
Gene ID:
112401
Antigen synonyms:
Testis-specic inhibitor of apoptosis|BIRC8|ILP-2|BIRC 8|Baculoviral IAP repeat containing 8|Inhibitor of apoptosis-like protein 2|BIRC8_HUMAN|IAP-like protein 2|Baculoviral IAP repeat-containing protein 8|hILP 2|ILP 2|Baculoviral IAP repeat containing protein 8|Testis specic inhibitor of apoptosis|IAP like protein 2|BIRC8 protein|hILP2|Inhibitor of apoptosis like protein 2
Modification:
Unmodified
Storage buffer:
Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
Molecular weight:
26 kDa
Storage temperature:
Store at ‒20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Concentration:
1 µg/µl
Shipping temperature:
4 °C
Immunogen:
KLH conjugated synthetic peptide derived from human ILP2
Tested applications:
ICC
Purification:
Purified by Protein A
Pack type:
Vial
Pk:
100 µl

Specifications

About this item

Protects against apoptosis mediated by BAX.Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibits specific proteases. A novel member in the IAP protein family was recently identified and designated ILP-2 for IAP-like protein-2 (1). ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues (1). ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9. These results suggest that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.

Type: Primary
Antigen: ILP2
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 141-236/236
Host: Rabbit
Isotype: IgG
Reactivity: Rat