Anti-AFF1 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Catalog # BOSSBS-5958R-A488

Supplier: Bioss

Catalog # BOSSBS-5958R-A488

Supplier: Bioss

Specifications

Antibody type:
Primary
Antigen name:
AF4/FMR2 Family, Member 1
Antigen symbol:
AFF1
Clonality:
Polyclonal
Conjugation:
Alexa Fluor® 488
Host:
Rabbit
ImmunoChemistry:
Yes
Isotype:
IgG
Reactivity:
Human,
Rat,
Mouse
Environmentally Preferable:
Cross adsorption:
No
Form:
liquid
Gene ID:
4299
Antigen synonyms:
MLLT2|AF4|PBM1
Storage buffer:
Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Storage temperature:
Store at 4°C for 12 months
Concentration:
1 μg/μl
Shipping temperature:
4°C
Purification:
Purified by Protein A
Pk:
100 µl

Specifications

About this item

Proto-oncogene AF-4 (or FEL) is a product of a chromosomal aberration of the human gene AFF1, which is associated with acute leukemias. The fusion of AF-4 on chromosome band 4q21 with the mixed lineage leukemia (MLL or HRX) gene on 11q23 results in a MLL-AF-4 chimeric transcription factor in which AF-4 contributes transcriptional effector properties and requires cell-specific accessory factors. MLL is involved in several chromosomal translocations associated with acute myeloid and lymphoid leukemia. The MLL-AF-4 fusion protein is expressed in all normal hematopoietic cells. The expression of MLL-AF-4 influences the production of protein cyclin-dependent kinase inhibitor (CDKN1B), suggesting that inhibition of MLL-AF-4 expression may be a powerful and highly specific treatment of chemotherapy-resistant leukemia.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: AFF1
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 488
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat