Anti-ABH1/ALKB Rabbit Polyclonal Antibody (Alexa Fluor® 680)

BOSSBS-12565R-A680

Anti-ABH1/ALKB Rabbit Polyclonal Antibody (Alexa Fluor® 680)

BOSSBS-12565R-A680

Antibody type:
Primary
Antigen name:
ABH1/ALKB
Clonality:
Polyclonal
Conjugation:
Alexa Fluor® 680
Host:
Rabbit
ImmunoChemistry:
Yes
ImmunoFluorescence:
Yes
Isotype:
IgG
Reactivity:
Rat,
Mouse
Western blot:
Yes
Environmentally Preferable:
Epitope:
1-100/389
Form:
Liquid
Gene ID:
8846
Antigen synonyms:
Alkylated DNA repair protein alkB homolog 1|ABH|hABH|Alkylation repair homolog 1|ALKB1_HUMAN|alkB|ALKBH1|DNA lyase ABH1|AlkB, alkylation repair homolog 1 E. coli|ABH1|Alkylation repair, alkB homolog|Alpha-ketoglutarate-dependent dioxygenase ABH1|ALKBH
Modification:
Unmodified
Storage buffer:
Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
Molecular weight:
44 kDa
Storage temperature:
Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Concentration:
1 µg/µl
Shipping temperature:
4 °C
Immunogen:
KLH conjugated synthetic peptide derived from human ABH1/ALKB
Tested applications:
ICC
Purification:
Purified by Protein A
Pack type:
Vial
Pk:
100 µl

ALKB protects DNA and RNA against damage from methylating compounds from the environment by directly reversing 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) cytotoxic alkylation lesions in DNA and RNA. The enzymes act by oxidative demethylation, utilizing ferrous iron and alpha-ketoglutarate as cofactors, 2-oxoglutarate as a co-substrate, and molecular oxygen as the oxidizing agent. Deficiencies in DNA and RNA repair in mammals are associated with cancer, neurological disease and developmental defects. ALKB plays a role in resistance to anti-cancer drugs which attempt to damage tumour DNA. Escherichia coli ALKB protein belongs to the superfamily of 2-oxoglutarate- and iron(II)-dependent oxygenases.

Type: Primary
Antigen: ABH1/ALKB
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 1-100/389
Host: Rabbit
Isotype: IgG
Reactivity: Mouse, Rat