Anti-SRPX2 Rabbit Polyclonal Antibody
Product Details & Documents
SRPX2 Antibody: Sushi-repeat-containing protein X-linked 2 (SRPX2) is a neural gene functioning in the speech and language center of the human brain; mutations in this gene lead to epilepsy, speech dyspraxia, mental retardation and cognitive disorders. Recently, SRPX2 was found to be a novel mediator of angiogenesis and can act as a ligand for the urokinase-type plasminogen activator, a protein that can facilitate invasive migration of sprouting endothelial cells. SRPX2 is also overexpressed in gastric cancer, leading to increased phosphorylation levels of focal adhesion kinase and enhanced cellular migration and adhesion, suggesting that SRPX2 may be a potential target in the treatment of metastatic cancers.
Type:
Antigen: SRPX2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
Documents
89417-222.pdf
Datasheet
Specifications
- Size:100 µg
- Western blot:Yes
- Clonality:Polyclonal
- Purification:Affinity chromatography purified via peptide column
- ImmunoFluorescence:Yes
- Isotype:IgG
- Host:Rabbit
- Antigen name:Sushi-Repeat Containing Protein, X-Linked 2
- Cat. No.:PRSI5475
- Reactivity:Human|Rat|Mouse
- Antigen synonyms:SRPX2_HUMAN.|a receptor that is a crucial component of the extracellular plasminogen proteolysis system. SRPX2 may be responsible for rolandic seizures RSs associated with oral and speech dyspraxia and mental retardation MR. The involvement of SRPX2 in these disorders suggests an important role for SRPX2 in the perisylvian region critical for language and cognitive development|migration and adhesion through FAK signaling in gastric and other cancer cells. Localized to the cytoplasm|including the rolandic area. It has been suggested that SRPX2 enhances cell motility|SRPX2 is a 465 amino acid secreted protein expressed in neurons of the brain|SRPX2 is a ligand for uPAR urokinase plasminogen activator
- Immunogen:SRPX2 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human SRPX2.
- ImmunoChemistry:Yes
- Conjugation:Unconjugated
- Tested applications:E, WB, IHC, IF
- Antigen symbol:SRPX2
- Storage buffer:PBS containing 0.02% sodium azide
- ELISA:Yes
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