Epithelial-derived neutrophil-activating peptide 78 (ENA 78), also known as CXCL5, is a chemokine that recruits neutrophils, promotes angiogenesis, and stimulates connective tissue remodelling. ENA 78 production is stimulated by interleukin 1 (IL-1) or tumor necrosis factor alpha (TNFα), and signals through the chemokine receptor CXCR2. ENA 78, 5-78aa is one of three naturally occurring ENA 78 variants in which the N-terminus has been truncated.

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