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- Antibody Type:Primary
- Antigen Name:Alpha-Hemoglobin Stabilizing Protein
- Antigen Symbol:aHSP
- Clonality:Polyclonal
- Conjugation:Biotin
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human
- Western Blot:Yes
- Size:200 µl
- Environmentally Preferable:
- Cross Adsorption:No
- Form:Liquid
- Gene ID:51327
- Antigen Synonyms:ERAF|Erythroid differentiation-related factor|EDRF|Erythroid Associated Factor|A-HSP
- Amino Acid Number:1 - 102
- UniProtKB:Q9NZD4
- Storage Buffer:0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol
- Molecular Weight:17 kDa
- Storage Temperature:Store at 2...8 °C for frequent use,−20 °C for 24 months. Avoid repeated freeze-thaw cycles.
- Concentration:0.5 mg/ml (for reference only)
- Shipping Temperature:Shipped on blue ice at 4 °C
- Immunogen:recombinant aHSP (Met1~Ser102)
- Purification:Antigen-specific affinity chromatography followed by Protein A affinity chromatography
- Cat. No.:MSPP-LA412HU71
- Packaging:Vial
Biotin-Linked Polyclonal Antibody to Alpha-Hemoglobin Stabilizing Protein (aHSP), derived from recombinant aHSP (Met1~Ser102), is reactive with Human.
- High specificity, affinity and purity
- Extensive validation and batch-to-batch consistency
- Diverse range of conjugated and custom options
- Comprehensive validation data and documentation
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High pressure induces an irreversible aggregation of the ferrous deoxy α-chains, whereas the AHSP/α-Hb complex shows reversible hexacoordination of the α-Hb without protein aggregation. Upon pressure release, the relaxation kinetics of the transition from the hexacoordinated to pentacoordinated form of α-Hb in the presence of AHSP exhibit a biphasic shape. High pressure did not induce dissociation of α-Hb from its chaperone, as evidenced by the ligand binding kinetics that show a unique rate for the AHSP/α-Hb complex. For both free α-Hb and the AHSP/α-Hb complex, the bimolecular rate constant of CO binding (kCOon) versus pressure exhibits a bell shape, attributed to the transition of the rate-determining step from the chemical barrier to the migration of CO within the protein matrix.
Type: Primary
Antigen: aHSP
Clonality: Polyclonal
Clone:
Conjugation: Biotin
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human