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Specifications
- Antibody Type:Primary
- Antigen Symbol:NRTN
- Clonality:Polyclonal
- ELISA:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:
- Reactivity:
- Size:100 µg
- Environmentally Preferable:
- Storage Temperature:Store vial at –20 °C. Aliquot contents and freeze at –20 °C. Centrifuge product if not completely clear after standing at room temperature. Stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use.
- Shipping Temperature:Dry Ice
- Purification:Affinity purified
- Cat. No.:75934-012
- Supplier no.:600-401-DA4
Specifications
About this item
Glial cell line-derived neurotrophic factor (GDNF) plays key roles in the control of vertebrate neuron survival and differentiation. A novel neurotrophic factor was recently cloned from human and mouse and designated neurturin. Physiological responses to neurturin (NTN) require the presence of receptor tyrosine kinase RET and a novel glycosylphosphatidylinositol linked receptor NTNRalpha. The cDNAs encoding NTNRalpha from human, rat, chicken, and mouse have been cloned recently and termed GDNFRb, Ret ligand 2 (RETL2) or TGF-beta-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRa-2 recently. NTN binds to and forms a complex with GFRa-2 and the Ret PTK and activates the RET receptor tyrosine kinase pathway. Both NTN and GDNF can activate the MAP kinase and phosphatidylinositol 3-kinase pathways and play a critical role in the development of many neuronal populations. Neurturin and GDNF define a new family of neurotrophic factors.
Anti-Neurturin Antibody has been tested for use in ELISA, Western Blotting, and Immunohistochemistry. Specific conditions for reactivity should be optimized by the end user. Expect a band at approximately 22 kDa in Western Blots of specific cell lysates and tissues.
Type: Primary
Antigen: NRTN
Clonality: Polyclonal
Clone:
Conjugation:
Epitope:
Host: Rabbit
Isotype:
Reactivity: