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Specifications
- Antibody Type:Primary
- Antigen Name:Membrane associated guanylate kinase inverted 1
- Antigen Symbol:MAGI1/IRSP58
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 488
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Rabbit,Human,Rat,Mouse
- Size:100 µL
- Environmentally Preferable:
- Cross Adsorption:No
- Form:liquid
- Antigen Synonyms:Fas ligand associated factor 3|Atrophin 1 interacting protein 3|Brain specific angiogenesis inhibitor 1 associated protein 2|atrophin-1 interacting protein 3|membrane associated guanylate kinase WW and PDZ domain containing 1|FLAF3|Gukmi1|Membrane associated guanylate kinase inverted 1|Insulin receptor substrate p53|Insulin receptor substrate protein of 53 kDa|BAP 1|AIP 3|Trinucleotide repeat containing gene 19 protein|Insulin receptor substrate p53/p58|MAGI1c|trinucleotide repeat-containing gene 19|IRSp53/58|BAIAP1|BAIAP 1|BAI1 associated protein 1|BAP2|WWP3.|AIP3|IRSP53|MAGI 1|BAP1|Trinucleotide repeat containing gene 19|BAI1-associated protein 1|WW domain-containing protein 3|MAGI-1|TNRC 19|Protein BAP2|WWP 3|BAI associated protein 2|WW domain containing protein 3|membrane associated guanylate kinase inverted-1|IRS 58|TNRC19
- Storage Buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Storage Temperature:Store at 4°C for 12 months
- Concentration:1 μg/μl
- Shipping Temperature:4°C
- Purification:Purified by Protein A
- Cat. No.:10254-068
- Supplier no.:BS-11352R-A488
Specifications
About this item
The membrane-associated guanylate kinase (MAGUK) proteins are concentrated at the membrane-cytoskeletal interface where they facilitate the assembly of multiprotein complexes on the inner surface of the plasma membrane. Three protein-protein interaction modules characteristically define MAGUK related proteins: the PDZ domain, the SH3 domain and the guanylate kinase (GuK) domain. The closely related MAGUK proteins, MAGI-1, MAGI-2 and MAGI-3 (membrane associated guanylate kinase inverted-1 and 2), likewise contain the GuK domain and five PDZ domains; however, the SH3 domain is replaced with a WW domain. The transcripts of MAGI-1 are alternatively spliced to produce three distinct proteins having unique C-terminals. Two variants, MAGI-1a and MAGI-1b, are associated with the membrane and cytosolic fractions and are primarily expressed in the brain. The third isoform, MAGI-1c, encodes for a nuclear localization signal that localizes MAGI-1c to the nucleus, and it is primarily expressed in the liver and kidney. MAGI-2 and MAGI-3 are localized to the plasma membrane, and they contribute to protein scaffolding by associating with the protein phosphatase PTEN.
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: MAGI1/IRSP58
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 488
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat, Rabbit