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Specifications
- Antibody Type:Primary
- Antigen Name:TBC1 Domain Family, Member 10C
- Antigen Symbol:TBC1D10C
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:
- Reactivity:Human,Mouse
- Western Blot:Yes
- Size:100 µg
- Environmentally Preferable:
- Epitope:N-Terminal
- Format:IgG
- Form:Liquid (sterile filtered)
- Gene ID:374403
- Antigen Synonyms:Carabin|CARABIN|EPI64C|TBC1 domain family member 10C
- Concentration:1 mg/mL by UV absorbance at 280 nm
- Shipping Temperature:Dry Ice
- Immunogen:Anti-Carabin antibody was prepared from whole rabbit serum produced by repeated immunizations with a 17 amino acid synthetic peptide from near the N-terminus of human Carabin.
- Purification:Anti-Carabin Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with Carabin from other sources has not been determined.
- Cat. No.:10800-520
- Supplier no.:600-401-AB3
Specifications
About this item
Antigen binding by the T-cell receptor (TCR) is one of the critical first steps in the immune response, triggering a cascade of signaling pathways that ultimately lead to T-cell activation. Screening a yeast two-hybrid screen of a human T-cell cDNA library with calcineurin, a protein phosphatase involved in multiple signaling pathways including T-cell activation, resulted in the identification of Carabin, a member of the TBC1 domain family of proteins, as a calcineurin-binding protein. Unlike other members of the TBC1 domain protein family which are thought to have a role in regulating cell growth and differentiation, further experiments demonstrated that Carabin is part of a negative regulatory loop for the intracellular TCR signaling pathway as well as an inhibitor of the Ras signaling pathway, suggesting that Carabin may also mediate crosstalk between calcineurin and Ras. Carabin antibody does not recognize TBC1D10A or TBC1D10B. Carabin is known to exist in multiple isoforms.
Recommended Dilutions: ELISA: 1:10,000-1:20,000; Immunohistochemsitry: 2.5 ?g/mL; Western Blot: 1-2 ?g/mL; contains 0.02% (w/v) Sodium Azide
Type: Primary
Antigen: TBC1D10C
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: N-Terminal
Host: Rabbit
Isotype:
Reactivity: Human, Mouse