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Specifications
- Antibody Type:Primary
- Antigen Name:TBC1 domain family, member 10C
- Antigen Symbol:TBC1D10C
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human,Mouse
- Western Blot:Yes
- Size:0.02 mg
- Environmentally Preferable:
- Cross Adsorption:No
- Form:Liquid
- Gene ID:Q8IV04
- Antigen Synonyms:TBC1D10C
- Storage Buffer:Carabin Antibody is supplied in PBS containing 0.02% sodium azide.
- Storage Temperature:Carabin antibody can be stored at 4 °C for three months and –20 °C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Concentration:1 mg/mL
- Shipping Temperature:4 °C
- Immunogen:Carabin antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human Carabin. The immunogen is located within the last 50 amino acids of Carabin.
- Purification:Carabin Antibody is affinity chromatography purified via peptide column.
- Cat. No.:10749-938
- Supplier no.:4267_S
Specifications
About this item
Carabin Antibody: Antigen binding by the T-cell receptor (TCR) is one of the critical first steps in the immune response, triggering a cascade of signaling pathways that ultimately lead to T-cell activation. Screening a yeast two-hybrid screen of a human T-cell cDNA library with calcineurin, a protein phosphatase involved in multiple signaling pathways including T-cell activation, resulted in the identification of Carabin, a member of the TBC1 domain family of proteins, as a calcineurin-binding protein. Unlike other members of the TBC1 domain protein family which are thought to have a role in regulating cell growth and differentiation, further experiments demonstrated that Carabin is part of a negative regulatory loop for the intracellular TCR signaling pathway as well as an inhibitor of the Ras signaling pathway, suggesting that Carabin may also mediate crosstalk between calcineurin and Ras. Carabin antibody does not recognize TBC1D10A or TBC1D10B. Carabin is known to exist in multiple isoforms.
Type: Primary
Antigen: TBC1D10C
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse