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Specifications
- Antibody Type:Primary
- Antigen Name:uracil-DNA glycosylase
- Antigen Symbol:UNG
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Western Blot:Yes
- Size:0.02 mg
- Environmentally Preferable:
- Epitope:near the C-Terminus
- Cross Adsorption:No
- Form:Liquid
- Gene ID:P13051
- Antigen Synonyms:UNG
- Storage Buffer:UNG1 Antibody is supplied in PBS containing 0.02% sodium azide.
- Storage Temperature:UNG1 antibody can be stored at 4 °C for three months and –20 °C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Concentration:1 mg/mL
- Shipping Temperature:4 °C
- Immunogen:UNG1 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human UNG1. The immunogen is located within the last 50 amino acids of UNG1.
- Purification:UNG1 Antibody is affinity chromatography purified via peptide column.
- Cat. No.:10748-620
- Supplier no.:3863_S
Specifications
About this item
UNG1 Antibody: The human uracil-DNA glycosylase (UNG) gene encodes both mitochondrial (UNG1) and nuclear (UNG2) forms through differentially regulated promotes and alternative splicing. While UNG2 is the major enzyme in the base excision repair pathway that removes uracil residues from nuclear DNA that arise through either misincorporation during replication or cytosine deamination, inhibition of UNG1 by uracil glycosylase inhibitor did not lead to increased levels of spontaneous or induced mitochondrial DNA mutations. However, decreased levels of UNG activity and increased oxidative damage to mitochondrial DNA were seen in older mice, suggesting that mitochondrial DNA repair mechanisms may be involved in various neurodegenerative disorders in an age-dependent manner. This UNG1 antibody will not cross-react with UNG2.
Type: Primary
Antigen: UNG
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat