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- Antibody Type:Primary
- Antigen Symbol:Noxa
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Host:Rabbit
- Isotype:IgG
- Reactivity:Mouse
- Western Blot:Yes
- Size:100 µL
- Environmentally Preferable:
- Epitope:75-90 aa
- Cross Adsorption:No
- Format:Lyophilized
- Antigen Synonyms:adult T cell leukemia-derived PMA-responsive|Immediate-early-response protein APR|PMA-induced protein 1|phorbol-12-myristate-13-acetate-induced protein 1|Noxa|PMAIP1|Pmaip1
- Immunogen:A synthetic peptide (CAQLRR IGDKVNLRQK) as part of mouse Noxa (aa: 75-90) conjugated to diphtheria toxoid
- Cat. No.:10782-434
- Supplier no.:R-124-100
The Bcl-2 family of proteins which regulate apoptosis share identical sequences called Bcl-2 Homology domains (BH1-4). The BH3 proteins, including BID, NOXA, PUMA, BIK, BIM and BAD are all pro-apoptotic and share sequence identity within the amphipathic alpha-helical BH3 region, which is essential for their apoptotic function. NOXA is highly expressed in adult T-cell leukemia cell line.
Western blot analysis of cells infected with Noxa adenoviruses and BAF indicates a high level of specificity for this antiserum.
Application Information:
WB. A dilution of 1:1000 to 1:2000 is recommended for this application. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Type: Primary
Antigen: Noxa
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: Mouse Noxa (aa: 75-90)
Host: Rabbit
Isotype: IgG
Reactivity: Mouse