To order chemicals, medical devices, or other restricted products please provide ID that includes your business name & shipping address via email [email protected] or fax 484.881.5997 referencing your VWR account number. Acceptable forms of ID are:
- • State issued document with your organization's Federal Tax ID Number
- • State issued document with your organization's Resale Tax ID Number
- • City or County issued Business License
- • State Department of Health Services License
- • Any other ID issued by the State that includes the business name & address
* ATTN: California Customers may require additional documentation as part of the CA Health & Safety Code. Products that fall under this regulation will be placed on a mandatory 21-day hold after documentation is received. Avantor will not lift restrictions for residential shipping addresses.
- Antibody Type:Primary
- Antigen Name:Retinoblastoma
- Antigen Symbol:Rb
- Clonality:Monoclonal
- Clone:2C4
- Conjugation:Unconjugated
- Host:Mouse
- Isotype:IgG1
- Reactivity:Human
- Western Blot:Yes
- Size:100 µg
- Environmentally Preferable:
- Form:Lyophilized
- Modification:phospho-Ser780
- Storage Buffer:PBS, pH 7.2, containing 1% sucrose. No preservatives. For a stock solution of 1.0mg/ml reconstitute with 100μl of sterile distilled water.
- Storage Temperature:–20 °C
- Shipping Temperature:Shipped on Blue Ice
- Immunogen:Synthetic peptide corresponding to a portion of human Rb phosphorylated at Ser780.
- Purification:purified by Protein A affinity chromatography
- Cat. No.:10050-134
- Supplier no.:KAM-CP121-E
The Retinoblastoma (Rb) is a tumor suppressor phosphoprotein that plays a critical role in the regulation of the cell cycle. In the absence of mitogenic signaling, Rb sequesters the transcription factor E2F within the cytosol. Upon phosphorylation, E2F is liberated from Rb and translocates to the nucleus where the latter facilitates gene transcription. Aberrations in the Rb gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.
Type: Primary
Antigen: Retinoblastoma protein
Clonality: Monoclonal
Clone: 2C4
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human