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Specifications
- Antibody Type:Primary
- Antigen Name:Complement C4
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 680
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:
- Size:100 µl
- Environmentally Preferable:
- Epitope:21-120/1744
- Form:Liquid
- Gene ID:720; 721
- Antigen Synonyms:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2|C4A|CH|Complement C4-A|Acidic complement C4|C4B1|C4B_2|C4A2|CPAMD2|C4B5|C4BD|C4A4|C4A3|C4F|C4B12|C4AD|C4B2|CPAMD3|C4S|C4A6|C4|RG|C4B3|CO4
- Modification:Unmodified
- Storage Buffer:Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- Molecular Weight:72/190 kDa
- Storage Temperature:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping Temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human Complement C4
- Tested Applications:ICC
- Purification:Purified by Protein A
- Cat. No.:76099-058
- Packaging:Vial
Specifications
About this item
Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
Type: Primary
Antigen: Complement C4
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 21-120/1744
Host: Rabbit
Isotype: IgG
Reactivity: