Polyclonal antibody for HIF 1 ALPHA/HIF1A detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. HIF 1 ALPHA/HIF1A information: Molecular Weight: 92670 MW; Subcellular Localization: Cytoplasm. Nucleus. Nucleus speckle . Colocalizes with HIF3A in the nucleus and speckles (By similarity). Cytoplasmic in normoxia, nuclear translocation in response to hypoxia. Colocalizes with SUMO1 in the nucleus, under hypoxia; Tissue Specificity: Expressed in most tissues with highest levels in kidney and heart. Overexpressed in the majority of common human cancers and their metastases, due to the presence of intratumoral hypoxia and as a result of mutations in genes encoding oncoproteins and tumor suppressors. A higher level expression seen in pituitary tumors as compared to the pituitary gland.

Type: Primary
Antigen: HIF-1-Alpha
Clonality: Polyclonal
Clone:
Conjugation:
Epitope:
Host:
Isotype: Rabbit
Reactivity: Human; Mouse; Rat