This antibody recognizes a 63 kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2 -dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts.
Type: Primary
Antigen: TOX3
Clonality: Monoclonal
Clone: TOX3/1123
Conjugation: Purified
Epitope:
Host: Mouse
Isotype: IgG2b kappa
Reactivity: Human
- Catalog No:
- BTIUBNUB1123-500
- BTIUBNUB1123-100
- Antigen symbol:
- TOX3
- TOX3
- Antigen name:
- TOX high mobility group box family member 3
- TOX high mobility group box family member 3
- Antigen synonyms:
- CAG trinucleotide repeat-containing gene F9 protein|CAGF9|Trinucleotide repeat containing 9 (TNRC9)|TOX3|TOX high mobility group box family member 3
- CAG trinucleotide repeat-containing gene F9 protein|CAGF9|Trinucleotide repeat containing 9 (TNRC9)|TOX3|TOX high mobility group box family member 3
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Conjugation:
- Unconjugated
- Unconjugated
- Clone:
- Clone TOX3/1123
- Clone TOX3/1123
- Reactivity:
- Human
- Human
- Host:
- Mouse
- Mouse
- Gene ID:
- 542050
- 542050
- Isotype:
- IgG2b kappa
- IgG2b kappa
- ImmunoChemistry:
- Yes
- Yes
- ImmunoFluorescence:
- Yes
- Concentration:
- 0,2 mg/ml
- 0,2 mg/ml
- Storage buffer:
- PBS/0,05% BSA/0,05% azide
- PBS/0,05% BSA/0,05% azide
: KIMBERLY CLARK
: VWR Collection
: VWR Chemicals
: VWR Chemicals
: VWR Collection
: VWR Collection
: VWR Collection
: VWR Collection