Specifications
- Antibody type:Primary
- Antigen name:GDN
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 680
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Western blot:Yes
- Environmentally Preferable:
- Epitope:301-398/398
- Form:Liquid
- Gene ID:5270
- Antigen synonyms:Plasminogen activator inhibitor type 1, member 2|Glia-derived nexin|SERPINE 2|GDN_HUMAN|GDN|P17 antibody Peptidase inhibitor 7|Glia derived nexin|PN1|Pi-7|PN-1|Serpin peptidase inhibitor, clade E nexin, plasminogen activator inhibitor type 1, member 2|Protease nexin I|Serpin E2|PNI|Serpine2|Protease inhibitor 7|Protease nexin 1
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:42 kDa
- Storage temperature:Store at –20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human GDN/SERPINE2
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Specifications
About this item
The serine protease inhibitors (serpins) compose a superfamily of proteins with a diverse set of functions, including the control of blood coagulation, complement activation, programmed cell death and development. Serpins are secreted glycoproteins that contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Protease nexin-1 (PN-1) is a serpin that inactivates several proteases, including thrombin, urokinase, plasminogen activators (PA) and plasmin. It is involved in tissue remodeling, cellular invasiveness, matrix degradation and tumor growth. PN-1 expression is abundant in the nervous system, where it inhibits thrombin, thereby playing a role in neural injury and repair processes. An imbalance between PN-1 and thrombin may be a contributing factor in the pathology of Alzheimer's disease.
Type: Primary
Antigen: GDN
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 301-398/398
Host: Rabbit
Isotype: IgG
Reactivity: Human; Mouse; Rat