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Anti-GDN Rabbit Polyclonal Antibody (ALEXA FLUOR® 680)
Anti-GDN Rabbit Polyclonal Antibody (ALEXA FLUOR® 680)
Catalog # BOSSBS-9845R-A680
Supplier:  Bioss
Anti-GDN Rabbit Polyclonal Antibody (ALEXA FLUOR® 680)
Catalog # BOSSBS-9845R-A680
Supplier:  Bioss

Specifications

  • Antibody type:
    Primary
  • Antigen name:
    GDN
  • Clonality:
    Polyclonal
  • Conjugation:
    Alexa Fluor® 680
  • Host:
    Rabbit
  • ImmunoChemistry:
    Yes
  • ImmunoFluorescence:
    Yes
  • Isotype:
    IgG
  • Reactivity:
    Human,
    Rat,
    Mouse
  • Western blot:
    Yes
  • Environmentally Preferable:
  • Epitope:
    301-398/398
  • Form:
    Liquid
  • Gene ID:
    5270
  • Antigen synonyms:
    Plasminogen activator inhibitor type 1, member 2|Glia-derived nexin|SERPINE 2|GDN_HUMAN|GDN|P17 antibody Peptidase inhibitor 7|Glia derived nexin|PN1|Pi-7|PN-1|Serpin peptidase inhibitor, clade E nexin, plasminogen activator inhibitor type 1, member 2|Protease nexin I|Serpin E2|PNI|Serpine2|Protease inhibitor 7|Protease nexin 1
  • Modification:
    Unmodified
  • Storage buffer:
    Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
  • Molecular weight:
    42 kDa
  • Storage temperature:
    Store at –20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
  • Concentration:
    1 µg/µl
  • Shipping temperature:
    4 °C
  • Immunogen:
    KLH conjugated synthetic peptide derived from human GDN/SERPINE2
  • Purification:
    Purified by Protein A
  • Pack type:
    Vial
  • Pk:
    100 µl

Specifications

About this item

The serine protease inhibitors (serpins) compose a superfamily of proteins with a diverse set of functions, including the control of blood coagulation, complement activation, programmed cell death and development. Serpins are secreted glycoproteins that contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Protease nexin-1 (PN-1) is a serpin that inactivates several proteases, including thrombin, urokinase, plasminogen activators (PA) and plasmin. It is involved in tissue remodeling, cellular invasiveness, matrix degradation and tumor growth. PN-1 expression is abundant in the nervous system, where it inhibits thrombin, thereby playing a role in neural injury and repair processes. An imbalance between PN-1 and thrombin may be a contributing factor in the pathology of Alzheimer's disease.

Type: Primary
Antigen: GDN
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 301-398/398
Host: Rabbit
Isotype: IgG
Reactivity: Human; Mouse; Rat

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