Anti-FEZ1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog # BOSSBS-9721R-A680

Supplier: Bioss

Catalog # BOSSBS-9721R-A680

Supplier: Bioss

Specifications

Antibody type:
Primary
Antigen name:
FEZ1
Clonality:
Polyclonal
Conjugation:
Alexa Fluor® 680
Host:
Rabbit
ImmunoChemistry:
Yes
ImmunoFluorescence:
Yes
Isotype:
IgG
Reactivity:
Human,
Rat,
Mouse
Western blot:
Yes
Environmentally Preferable:
Epitope:
301-392/392
Form:
Liquid
Gene ID:
9638
Antigen synonyms:
Zygin I|Fez 1|Fezl|Zpf312|Zygin1|Fasciculation and elongation protein zeta-1|Zygin 1|FEZ1|ZyginI|FEZ1_HUMAN|Fez|Fasciculation and elongation protein zeta 1|Fez-like zinc finger protein|Zygin-1|Forebrain embryonic zinc-finger like protein
Modification:
Unmodified
Storage buffer:
Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
Storage temperature:
Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Concentration:
1 µg/µl
Shipping temperature:
4 °C
Immunogen:
KLH conjugated synthetic peptide derived from human FEZ1
Purification:
Purified by Protein A
Pack type:
Vial
Pk:
100 µl

Specifications

About this item

Frequent loss of heterozygosity (LOH) at human chromosome 8p22-p21 is associated with various tumours including prostate and breast cancer. The 8p22-p21 region contains the FEZ1 gene, which is altered in tumours of the esophagus, prostate and breast. The FEZ1 protein (also known as leucine zipper putative tumour suppressor or LZTS1) contains a DNA-binding leucine zipper motif. FEZ1 is expressed in normal breast and prostate, but alterations in FEZ1 expression result in abnormal cell growth. The absence of FEZ1 expression is characteristic of breast and prostate cancer cell lines as well as primary breast and pro-state tumours. This absence of FEZ1 may be due to several factors, including mutations in the FEZ1 gene or hypermethylation of the CpG island flanking the FEZ1 promoter region. FEZ1 acts as a negative regulator of cell growth. During cell-cycle progression, FEZ1 localizes to microtubule components and is hyperphosphorylated by cAMP-dependent kinase.

Type: Primary
Antigen: FEZ1
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 301-392/392
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat