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Anti-ALAS1 Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Anti-ALAS1 Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Catalog # BOSSBS-9527R-A750
Supplier:  Bioss
Anti-ALAS1 Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Catalog # BOSSBS-9527R-A750
Supplier:  Bioss

Specifications

  • Antibody type:
    Primary
  • Antigen name:
    ALAS1
  • Clonality:
    Polyclonal
  • Conjugation:
    Alexa Fluor® 750
  • Host:
    Rabbit
  • ImmunoChemistry:
    Yes
  • ImmunoFluorescence:
    Yes
  • Isotype:
    IgG
  • Reactivity:
    Human,
    Rat,
    Mouse
  • Western blot:
    Yes
  • Environmentally Preferable:
  • Epitope:
    161-260/640
  • Form:
    Liquid
  • Gene ID:
    211
  • Antigen synonyms:
    Alas 1|5-aminolevulinate synthase|ALAS-H|alaS1|nonspecic|Delta aminolevulinate synthase|ALAS|ALAS N|Migration inducing protein 4|ALAS H|5 aminolevulinate synthase nonspecic mitochondrial|mitochondrial|5 aminolevulinate synthase|ALAS 3|MIG4|HEM1_HUMAN|Delta ALA synthetase|ALASH|5-aminolevulinic acid synthase 1|Delta-ALA synthase 1|Aminolevulinate delta synthase 1|ALAS3|MIG 4|Delta-aminolevulinate synthase 1|Aminolevulinic acid synthase 1|5 aminolevulinic acid synthase
  • Modification:
    Unmodified
  • Storage buffer:
    Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
  • Storage temperature:
    Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
  • Concentration:
    1 µg/µl
  • Shipping temperature:
    4 °C
  • Immunogen:
    KLH conjugated synthetic peptide derived from human ALAS1/ALAS-H
  • Purification:
    Purified by Protein A
  • Pack type:
    Vial
  • Pk:
    100 µl

Specifications

About this item

5-aminolevulinate synthase 1 (ALAS-H) and 2 (ALAS-E) are two isoforms of ALAS, an enzyme catalyzing the first step of the heme biosynthetic pathway in mammals. The erythroid-specific isoenzyme, ALAS-E, regulates the first step of hematopoietic cell differentiation and iron metabolism in the liver. ALAS-H is a housekeeping protein which mediates synthesis of early heme in the mitochondria of most cells. Succinyl CoA associates with ALAS-E in protein conformation change and translocation of ALAS-E into the mitochondria and does not interact with ALAS-H. The ALAS-E 5'-flanking region contains binding sites for nuclear activators such as GATA-1, NF-E2 and EKLF. Since the ALAS gene maps to the X chromosome, mutation of the gene leads to the pyridoxine-refractory X-linked sideroblastic anemia.

Type: Primary
Antigen: ALAS1
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 161-260/640
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

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