Specifications
- Antibody type:Primary
- Antigen name:ALAS1
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 750
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Western blot:Yes
- Environmentally Preferable:
- Epitope:161-260/640
- Form:Liquid
- Gene ID:211
- Antigen synonyms:Alas 1|5-aminolevulinate synthase|ALAS-H|alaS1|nonspecic|Delta aminolevulinate synthase|ALAS|ALAS N|Migration inducing protein 4|ALAS H|5 aminolevulinate synthase nonspecic mitochondrial|mitochondrial|5 aminolevulinate synthase|ALAS 3|MIG4|HEM1_HUMAN|Delta ALA synthetase|ALASH|5-aminolevulinic acid synthase 1|Delta-ALA synthase 1|Aminolevulinate delta synthase 1|ALAS3|MIG 4|Delta-aminolevulinate synthase 1|Aminolevulinic acid synthase 1|5 aminolevulinic acid synthase
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Storage temperature:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human ALAS1/ALAS-H
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Specifications
About this item
5-aminolevulinate synthase 1 (ALAS-H) and 2 (ALAS-E) are two isoforms of ALAS, an enzyme catalyzing the first step of the heme biosynthetic pathway in mammals. The erythroid-specific isoenzyme, ALAS-E, regulates the first step of hematopoietic cell differentiation and iron metabolism in the liver. ALAS-H is a housekeeping protein which mediates synthesis of early heme in the mitochondria of most cells. Succinyl CoA associates with ALAS-E in protein conformation change and translocation of ALAS-E into the mitochondria and does not interact with ALAS-H. The ALAS-E 5'-flanking region contains binding sites for nuclear activators such as GATA-1, NF-E2 and EKLF. Since the ALAS gene maps to the X chromosome, mutation of the gene leads to the pyridoxine-refractory X-linked sideroblastic anemia.
Type: Primary
Antigen: ALAS1
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 161-260/640
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat