ZORBAX® Extend-C18 columns have high efficiency and a long life at high pH upto pH 11,5 with more effieincy and better peak shape than polymer-based columns.

• Improve retention, resolution and peak shape of basic compounds
• High sensitivity for LC/MS separations of peptides and proteins

Extend-C18 columns incorporate a unique patented bidentate silane, combined with a double-endcapping process that protects the silica from dissolution at high pH upto pH 11,5.

Columns are best applied for separations of compounds that are either:
(1) Basic and have little or no retention at low or intermediate pH
(2) More stable or more soluble at high pH
(3) Basic and show poor peak shape at low or intermediate pH