ZAP70 is a 70 kDa protein tyrosine kinase found in T-cells and natural killer cells.Control of this protein translation is via the IgVH gene. ZAP70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well.Anti-ZAP70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP70 negative) and Ig-unmutated (anti-ZAP70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis.
Type: Primary
Antigen: ZAP70
Clonality: Monoclonal
Clone: ZAP70/528
Conjugation: CF594
Epitope:
Host: Mouse
Isotype: IgG2a, kappa
Reactivity: Human
- Catalog No:
- BNC940528-500
- BNC940528-100
- Antigen symbol:
- ZAP70
- ZAP70
- Antigen synonyms:
- Selective T cell defect|SRK|Tyrosine-protein kinase ZAP-70|Zeta chain associated protein kinase 70kDa|TZK|Syk-related tyrosine kinase|STD
- Selective T cell defect|SRK|Tyrosine-protein kinase ZAP-70|Zeta chain associated protein kinase 70kDa|TZK|Syk-related tyrosine kinase|STD
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Conjugation:
- CF® 594
- CF® 594
- Clone:
- Clone ZAP70/528
- Clone ZAP70/528
- Reactivity:
- Human
- Human
- Host:
- Mouse
- Mouse
- Gene ID:
- 234569
- 234569
- Isotype:
- IgG2a kappa
- IgG2a kappa
- ImmunoChemistry:
- Yes
- Yes
- ImmunoFluorescence:
- Yes
- Concentration:
- 0,1 mg/ml
- 0,1 mg/ml
- Storage buffer:
- PBS/0,1% BSA/0,05% azide
- PBS/0,1% BSA/0,05% azide
: VWR Chemicals
: VWR Chemicals
: VWR Collection
: KIMBERLY CLARK
: VWR Collection
: VWR Collection
: VWR Collection
: VWR Collection