Anti-PHD1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

BOSSBS-4251R-A680

Anti-PHD1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

BOSSBS-4251R-A680

Antibody type:
Primary
Antigen name:
PHD1
Clonality:
Polyclonal
Conjugation:
Alexa Fluor® 680
Host:
Rabbit
ImmunoChemistry:
Yes
ImmunoFluorescence:
Yes
Isotype:
IgG
Reactivity:
Mouse
Western blot:
Yes
Environmentally Preferable:
Epitope:
321-407/407
Form:
Liquid
Gene ID:
112398
Antigen synonyms:
EIT 6|EGLN2|H PH1|H P4H 1|EGLN2_HUMAN|EIT6|EGL nine C.elegans homolog 2|PHD 1|Egl nine homolog 2|EGLN 2|prolyl hydroxylase|HPH3|PHD1|HPH 3|HPH1|P4H1
Modification:
Unmodified
Storage buffer:
Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
Molecular weight:
44 kDa
Storage temperature:
Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Concentration:
1 µg/µl
Shipping temperature:
4 °C
Immunogen:
KLH conjugated synthetic peptide derived from human PHD1/prolyl hydroxylase
Tested applications:
ICC
Purification:
Purified by Protein A
Pack type:
Vial
Pk:
100 µl

PHD1 catalyses the posttranslational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins and hydroxylates HIF-1 alpha at Pro-402 and Pro-564, and HIF-2 alpha. It functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitylation complex. It may play a role in cell growth regulation.

Type: Primary
Antigen: PHD1
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 321-407/407
Host: Rabbit
Isotype: IgG
Reactivity: Mouse