Recombinant protein of human mitogen-activated protein kinase 14 (MAPK14), transcript variant. Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.

• Predicted molecular weight: 41,3 kDa
• Buffer: 25 mM Tris-HCl, 100 mM glycine, pH 7,3, 10% glycerol
• Expression host: HEK293T

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response.

For testing in cell culture applications, please filter before use.

Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.