Specifications
- Antibody type:Primary
- Antigen name:SLC25A12/ARALAR
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 750
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Mouse
- Western blot:Yes
- Environmentally Preferable:
- Epitope:101-200/678
- Form:Liquid
- Antigen synonyms:ARALAR1|CMC1_HUMAN|solute carrier family 25, member 12|Araceli hiperlarga|Mitochondrial aspartate glutamate carrier 1|Calcium-binding mitochondrial carrier protein Aralar1|Solute carrier family 25 member 12|ARALAR|Calcium binding mitochondrial carrier superfamily member|AGC1|SLC25A12
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:75 kDa
- Storage temperature:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human SLC25A12/ARALAR
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Specifications
About this item
Calcium Signalling in mitochondria is important in order for it to function in response to a variety of extracellular stimuli. Signalling begins with Ca²⁺ entry in mitochondria via the Ca²⁺ uniporter followed by Ca²⁺ activation of three dehydrogenases in the mitochondrial matrix. ARALAR, the neuronal Ca²⁺-binding mitochondrial aspartate-glutamate carrier, has Ca²⁺ binding domains facing the extramitochondrial space and functions in the malate-aspartate NADH shuttle (MAS). ARALAR is encoded by the SLC25A12 gene and is expressed in brain and skeletal muscle. ARALAR is required for the synthesis of brain aspartate and N-acetylaspartatemay and plays a role in myelin formation. It is also essential for the transmission of small Ca²⁺ signals to mitochondria via an increase in mitochondrial NADH. In addition, ARALAR is implicated in conferring susceptibility to schizophrenia.
Type: Primary
Antigen: SLC25A12/ARALAR
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 101-200/678
Host: Rabbit
Isotype: IgG
Reactivity: Mouse