Acetaldehyde diethyl acetal is one of the precursors utilised for the synthesis of fragrances and pharmaceutical products.

Acetaldehyde diethyl acetal may be used as a reference standard for the determination of acetaldehyde diethyl acetal in: wine vinegars by headspace sorptive extraction−thermal desorption−gas chromatography−mass spectrometry (HSSE−TD−GC−MS); distilled spirits by GC with flame ionisation detection (FID) as well as GC-FID-MS; organic red wines derived from Saccharomyces cerevisiae strains by GC-FID as well as HSSE-GC−MS; cognac (brandy) by HS-GC-MS.